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Synthesis of Quinazolines from N,N'-Disubstituted Amidines via I2/KI-Mediated Oxidative C-C Bond Formation

Zhigang Lv, Bingnan Wang, Zhiyuan Hu, Yiming Zhou, Wenquan Yu* and Junbiao Chang*

*College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan Province 450001, China, Email:,

Z. Lv, B. Wang, Z. Hu, Y. Zhou, W. Yu, J. Chang, J. Org. Chem., 2016, 81, 9924-9930.

DOI: 10.1021/acs.joc.6b02100

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An I2/KI-promoted oxidative C-C bond formation reaction from C(sp3)-H and C(sp2)-H bonds enables the constructions of quinazolines in good yields from N,N'-disubstituted amidines, which are readily prepared. This practical and environmentally benign approach works well with crude amidine intermediates and can also be carried out on a gram scale.

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Key Words

Quinazolines, Iodine

ID: J42-Y2016