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Hydrogen Peroxide Promoted Metal-Free Oxidation/Cyclization of α-Hydroxy N-Arylamides: A Facile One-Pot Synthesis of Isatins

Jie Li, Xu Cheng, Xiaojun Ma, Guanghui Lv, Zhen Zhan, Mei Guan*, Yong Wu*

*West China Hospital and West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. of China, Email:,

J. Li, X. Cheng, X. Ma, G. Lv, Z. Zhan, M. Guan, Y. Wu, Synlett, 2016, 27, 2485-2488.

DOI: 10.1055/s-0035-1562517


An efficient and environmentally friendly conversion of α-hydroxy N-arylamides into isatins in very good yields proceeded smoothly under metal-free conditions in the presence of hydrogen peroxide as oxidant. This convenient method offers broad substrate scope.

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Key Words

hydrogen peroxide, hydroxy amides, isatins, cyclization, indoles

ID: J60-Y2016