Inherent vs Apparent Chemoselectivity in the Kumada-Corriu Cross-Coupling Reaction
XiYe Hua, Jeanne Masson-Makdissi, Ryan J. Sullivan and Stephen G. Newman*
*Centre for Catalysis Research and Innovation, Department of
Chemistry and Biomolecular Sciences, University of Ottawa, 10 Marie-Curie,
Ottawa, Ontario, Canada, K1N 6N5, Email: stephen.newman
uottawa.ca
X. Hua, J. M. Makdissi, R. J. Sullivan, S. G. Newman, Org. Lett., 2016, 18, 5312-5315.
DOI: 10.1021/acs.orglett.6b02631
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Abstract
High-yielding Kumada couplings can occur in the presence of many electrophilic and heterocyclic functional groups if oxidative addition rates are matched with the rate of syringe pump addition of the Grignard reagent.
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Key Words
ID: J54-Y2016
