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N,N-Dimethylformamide as Hydride Source in Nickel-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated Esters

Siyu Guo and Jianrong (Steve) Zhou*

*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371 Singapore, Email:

S. Guo, J. Zhou, Org. Lett., 2016, 18, 5344-5347.

DOI: 10.1021/acs.orglett.6b02662

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A nickel/bisphosphine catalyst enables an asymmetric transfer hydrogenation of α,β-unsaturated esters in the presence of N,N-dimethylformamide (DMF) as the hydride source.

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Asymmetric Umpolung Hydrogenation and Deuteration of Alkenes Catalyzed by Nickel

S. Guo, X. Wang, J. S. Zhou, Org. Lett., 2020, 22, 1204-1207.

Key Words

reduction of α,β-unsaturated compounds

ID: J54-Y2016