N,N-Dimethylformamide as Hydride Source in Nickel-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated Esters
Siyu Guo and Jianrong (Steve) Zhou*
*Division of Chemistry and Biological Chemistry, School of
Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang
Link, 637371 Singapore, Email: jrzhou
ntu.edu.sg
S. Guo, J. Zhou, Org. Lett., 2016, 18, 5344-5347.
DOI: 10.1021/acs.orglett.6b02662
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Abstract
A nickel/bisphosphine catalyst enables an asymmetric transfer hydrogenation of α,β-unsaturated esters in the presence of N,N-dimethylformamide (DMF) as the hydride source.
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Asymmetric Umpolung Hydrogenation and Deuteration of Alkenes Catalyzed by Nickel
S. Guo, X. Wang, J. S. Zhou, Org. Lett., 2020, 22, 1204-1207.
Key Words
reduction of α,β-unsaturated compounds
ID: J54-Y2016
