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Ambient Decarboxylative Arylation of Malonate Half-Esters via Oxidative Catalysis

Patrick J. Moon, Shengkang Yin and Rylan J. Lundgren*

*Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada, Email:

P. J. Moon, S. Yin, R. J. Lundgren, J. Am. Chem. Soc., 2016, 138, 13826-13829.

DOI: 10.1021/jacs.6b08906

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The merger of aerobic oxidative Cu catalysis with decarboxylative enolate interception enables a decarboxylative carbonyl α-arylation of arylboron nucleophiles with malonic acid derivatives. This method converts substrates containing electrophilic functional groups that are incompatible with existing α-arylation methods.

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Key Words

α-arylation, oxygen

ID: J48-Y2016