Enantioselective Michael Addition of Malonates to Chalcone Derivatives Catalyzed by Dipeptide-derived Multifunctional Phosphonium Salts
Dongdong Cao, Guosheng Fang, Jiaxing Zhang, Hongyu Wang, Changwu Zheng and Gang Zhao*
*Key Laboratory of Synthetic Chemistry of Natural Substances,
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345
Lingling Road, Shanghai 200032, China, Email: zhaog
mail.sioc.ac.cn
D. Cao, G. Fang, J. Zhang, H. Wang, C. Zheng, G. Zhao, J. Org. Chem., 2016, 81, 9973-9982.
DOI: 10.1021/acs.joc.6b01752
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Abstract
A highly enantioselective Michael addition of malonates to enones is catalyzed by dipeptide-derived multifunctional phosphonium salts. This catalytic system offers wide substrate scope and gram scale-up synthesis of adducts with both excellent yield and enantioselectivity.
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Key Words
conjugate addition of active methylene compounds, organocatalysis
ID: J42-Y2016
