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Electrophilic Fluorination of Secondary Phosphine Oxides and Its Application to P-O Bond Construction

Qian Chen*, Jiekun Zeng, Xinxing Yan, Yulin Huang, Chunxiao Wen, Xingguo Liu and Kun Zhang

*School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, Guangdong 510006, China, Email:

Q. Chen, J. Zeng, X. Yan, Y. Huang, C. Wen, X. Liu, K. Zhang, J. Org. Chem., 2016, 81, 10043-10048.

DOI: 10.1021/acs.joc.6b01932

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An efficient electrophilic fluorination of secondary phosphine oxides with Selectfluor provides direct access to phosphoric fluorides in good yield under mild conditions. In addition, one-pot P-O bond construction is achieved in the presence of water or alcohols to provide phosphinic acids or phosphinates.

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Key Words

fluorination, oxidation, Selectfluor

ID: J42-Y2016