Electrophilic Fluorination of Secondary Phosphine Oxides and Its Application to P-O Bond Construction
Qian Chen*, Jiekun Zeng, Xinxing Yan, Yulin Huang, Chunxiao Wen, Xingguo Liu and Kun Zhang
*School of Chemical Engineering and Light Industry, Guangdong
University of Technology, Guangzhou, Guangdong 510006, China, Email: qianchen
gdut.edu.cn
Q. Chen, J. Zeng, X. Yan, Y. Huang, C. Wen, X. Liu, K. Zhang, J. Org. Chem., 2016, 81, 10043-10048.
see article for more reactions
Abstract
An efficient electrophilic fluorination of secondary phosphine oxides with Selectfluor provides direct access to phosphoric fluorides in good yield under mild conditions. In addition, one-pot P-O bond construction is achieved in the presence of water or alcohols to provide phosphinic acids or phosphinates.
see article for more examples
Key Words
fluorination, oxidation, Selectfluor
ID: J42-Y2016
