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One-Pot Reactions for Modular Synthesis of Polysubstituted and Fused Pyridines

Zhidong Song, Xin Huang, Wenbin Yi* and Wei Zhang*

*Nanjing University of Science and Technology, Nanjing 210094, P. R. China; University of Massachusetts Boston, Boston, Massachusetts 02125, United States, Email:,

Z. Song, X. Huang, W. Yi, W. Zhang, Org. Lett., 2016, 18, 5640-5643.

DOI: 10.1021/acs.orglett.6b02883 (free Supporting Information)

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A 2-fluoro-1,3-dicarbonyl-initiated one-pot Michael addition/[5 + 1] annulation/dehydrofluorinative aromatization reaction sequence enables a transition-metal catalyst-free, regioselective synthesis of di-, tri-, tetra-, and pentasubstituted pyridines as well as fused pyridines from readily available starting materials.

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Key Words


ID: J54-Y2016