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Alkyl Nitrites: Novel Reagents for One-Pot Synthesis of 3,5-Disubstituted Isoxazoles from Aldoximes and Alkynes

Kishorkumar S. Kadam, Thirumanavelan Gandhi*, Amol Gupte, A. K. Gangopadhyay, Rajiv Sharma

*Department of Chemistry, School of Advanced Sciences, VIT University, Vellore 632014, Tamil Nadu, India, Email:

K. S. Kadam, T. Gandhi, A. Gupte, A. K. Gangopadhyay, R. Sharma, Synthesis, 2016, 48, 3996-4008.

DOI: 10.1055/s-0035-1561464

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The use of either tert-butyl nitrite or isoamyl nitrite enables an efficient, one-pot approach for the synthesis of 3,5-disubstituted isoxazoles from substituted aldoximes and alkynes under conventional heating conditions.

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Key Words

isoxazoles, nitrile oxides, aldoximes, tert-butyl nitrite, isoamyl nitrite

ID: J66-Y2016