Nickel-Catalyzed Diaryl Ketone Synthesis by N-C Cleavage: Direct Negishi Cross-Coupling of Primary Amides by Site-Selective N,N-Di-Boc Activation
Shicheng Shi and Michal Szostak*
*Department of Chemistry, Rutgers University, 73 Warren Street, Newark, New Jersey 07102, United States, Email: michal.szostakrutgers.edu
S. Shi, M. Szostak, Org. Lett., 2016, 18, 5872-5875.
DOI: 10.1021/acs.orglett.6b02952 (free Supporting Information)
Nickel catalysis and a site-selective N,N-di-Boc activation enable a general Negishi acylation of primary amides. The reaction is promoted by a bench-stable, inexpensive Ni catalyst and shows excellent functional group compatibility.
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