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Nickel-Catalyzed Diaryl Ketone Synthesis by N-C Cleavage: Direct Negishi Cross-Coupling of Primary Amides by Site-Selective N,N-Di-Boc Activation

Shicheng Shi and Michal Szostak*

*Department of Chemistry, Rutgers University, 73 Warren Street, Newark, New Jersey 07102, United States, Email:

S. Shi, M. Szostak, Org. Lett., 2016, 18, 5872-5875.

DOI: 10.1021/acs.orglett.6b02952 (free Supporting Information)


Nickel catalysis and a site-selective N,N-di-Boc activation enable a general Negishi acylation of primary amides. The reaction is promoted by a bench-stable, inexpensive Ni catalyst and shows excellent functional group compatibility.

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Key Words

aryl ketones

ID: J54-Y2016