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Access to Thiazole via Copper-Catalyzed [3+1+1]-Type Condensation Reaction under Redox-Neutral Conditions

Xiaodong Tang, Jidan Yang, Zhongzhi Zhu, Meifang Zheng, Wanqing Wu and Huanfeng Jiang*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China, Email:

X. Tang, J. Yang, Z. Zhu, M. Zheng, W. Wu, H. Jiang, J. Org. Chem., 2016, 81, 11461-11466.

DOI: 10.1021/acs.joc.6b02124

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A copper-catalyzed [3+1+1]-type condensation of oximes, anhydrides and potassiumthiocyanate (KSCN) provides thiazoles in very good yields under mild reaction conditions. The transformation has good functional group tolerance.

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Key Words

thiazoles, multicomponent reactions

ID: J42-Y2016