A General, One-Pot Method for the Synthesis of Sulfinic Acids from Methyl Sulfones
Donald R. Gauthier Jr.* and Naoki Yoshikawa
*Process Research & Development, Merck Research Laboratories,
126 East Lincoln Avenue, P.O. Box 2000, Rahway, New Jersey 07065, United States, Email:
donald_gauthier
merck.com
D. R. Gauthier, Jr., N. Yoshikawa, Org. Lett., 2016, 18, 5994-5997.
DOI: 10.1021/acs.orglett.6b02723
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Abstract
A simple and efficient method for converting methyl sulfones to sulfinic acids involves alkylation with a benzylic halide, followed by in situ elimination of the resulting styrene in the presence of excess base to yield a sulfinic acid in a single reaction process.
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Key Words
ID: J54-Y2016
