Sustainable Synthesis of Quinolines and Pyrimidines Catalyzed by Manganese PNP Pincer Complexes
Matthias Mastalir, Mathias Glatz, Ernst Pittenauer, GŁnter Allmaier and Karl Kirchner*
*Institute of Applied Synthetic Chemistry and ‡Institute of Chemical Technologies and Analytics, Vienna University of Technology, Getreidemarkt 9, A-1060 Wien, Austria, Email: karl.kirchnertuwien.ac.at
M. Mastalir, M. Glatz, E. Pittenauer, G. Allmaier, K. Kirchner, J. Am. Chem. Soc., 2016, 138, 15303-15306.
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A hydride Mn(I) PNP pincer complex catalyzes environmentally benign, sustainable, and practical syntheses of substituted quinolines and pyrimidines using combinations of 2-aminobenzyl alcohols and alcohols as well as benzamidine and two different alcohols, respectively. The reactions proceed with high atom efficiency via a sequence of dehydrogenation and condensation steps in very good isolated yields.
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