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Ester Formation via Nickel-Catalyzed Reductive Coupling of Alkyl Halides with Chloroformates

Min Zheng, Weichao Xue, Teng Xue and Hegui Gong*

*Center for Supramolecular Chemistry and Catalysis and Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China, Email:

M. Zheng, W. Xue, T. Xue, H. Gong, Org. Lett., 2016, 18, 6152-6155.

DOI: 10.1021/acs.orglett.6b03158


A mild Ni-catalyzed reductive coupling enables the synthesis of alkyl esters from readily available alkyl halides and chloroformates. Unactivated primary and secondary alkyl iodides as well as glycosyl, benzyl, and aminomethyl halides provide products in good yields with high functional group tolerance.

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Key Words

esters, zinc

ID: J54-Y2016