Cu-Catalyzed [3 + 3] Annulation for the Synthesis of Pyrimidines via β-C(sp3)-H Functionalization of Saturated Ketones
Jun-Long Zhan, Meng-Wei Wu, Fei Chen and Bing Han*
*State Key Laboratory of Applied Organic Chemistry, College
of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P.
R. China, Email: hanb
lzu.edu.cn
J.-L. Zhang, M.-W. Wu, F. Chen, B. Han, J. Org. Chem., 2016, 81, 11994-12000.
DOI: 10.1021/acs.joc.6b02181
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Abstract
A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.
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Key Words
ID: J42-Y2016
