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Cu-Catalyzed [3 + 3] Annulation for the Synthesis of Pyrimidines via β-C(sp3)-H Functionalization of Saturated Ketones

Jun-Long Zhan, Meng-Wei Wu, Fei Chen and Bing Han*

*State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, P. R. China, Email:

J.-L. Zhang, M.-W. Wu, F. Chen, B. Han, J. Org. Chem., 2016, 81, 11994-12000.

DOI: 10.1021/acs.joc.6b02181

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A Cu-catalyzed and 4-HO-TEMPO-mediated [3 + 3] annulation of commercially available amidines with saturated ketones enables an efficient and facile synthesis of structurally important pyrimidines via a cascade reaction of oxidative dehydrogenation/annulation/oxidative aromatization.

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Key Words

Pyrimidines, 4-HO-TEMPO

ID: J42-Y2016