Ultrasound-Promoted Synthesis of 4-Pyrimidinols and Their Tosyl Derivatives
Matías Vidal, Macarena García-Arriagada, Marcos Caroli Rezende, Moisés Domínguez*
*Facultad de Química y Biología, Universidad de Santiago de
Chile, Av. Bernardo O'Higgins 3363, Santiago, Chile, Email: moises.dominguez
usach.cl
M. Vidal, M. García-Arriagada, M. C. Rezende, M. Domínguez, Synthesis, 2016, 48, 4246-4252.
DOI: 10.1055/s-0035-1562788
see article for more reactions
Abstract
Ultrasound irradiation promoted the cyclocondensation of β-keto esters and amidines in good to excellent yields to form highly substituted 4-pyrimidinols. A subsequent ultrasound-promoted tosylation followed by a Suzuki-Miyaura cross-coupling provides 4-arylpyrimidines.
see article for more examples
Key Words
condensation, ultrasound, sonochemistry, pyrimidinols, pyrimidines, tosylation, cross-coupling
ID: J66-Y2016
