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Ultrasound-Promoted Synthesis of 4-Pyrimidinols and Their Tosyl Derivatives

Matías Vidal, Macarena García-Arriagada, Marcos Caroli Rezende, Moisés Domínguez*

*Facultad de Química y Biología, Universidad de Santiago de Chile, Av. Bernardo O'Higgins 3363, Santiago, Chile, Email:

M. Vidal, M. García-Arriagada, M. C. Rezende, M. Domínguez, Synthesis, 2016, 48, 4246-4252.

DOI: 10.1055/s-0035-1562788 (free Supporting Information)

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Ultrasound irradiation promoted the cyclocondensation of β-keto esters and amidines in good to excellent yields to form highly substituted 4-pyrimidinols. A subsequent ultrasound-promoted tosylation followed by a Suzuki-Miyaura cross-coupling provides 4-arylpyrimidines.

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Key Words

condensation, ultrasound, sonochemistry, pyrimidinols, pyrimidines, tosylation, cross-coupling

ID: J66-Y2016