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E- and Z-Selective Transfer Semihydrogenation of Alkynes Catalyzed by Standard Ruthenium Olefin Metathesis Catalysts

Rafał Kusy and Karol Grela*

*Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, P.O. Box 58, 01-224 Warsaw, Poland, Email:

R. Kusy, K. Grela, Org. Lett., 2016, 18, 6196-6199.

DOI: 10.1021/acs.orglett.6b03254

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Commercial first and second generation Hoveyda-Grubbs catalysts enable a selective transfer semihydrogenation of alkynes to yield alkenes in the presence of formic acid as a hydrogen donor. This catalytic system tolerates many functional groups (halogens, cyano, nitro, sulfide, alkenes).

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Key Words

semireduction of alkynes, formic acid

ID: J54-Y2016