Regioselective Thiocarbonylation of Vinyl Arenes
Vera Hirschbeck, Paul H. Gehrtz and Ivana Fleischer*
*Institute of Organic Chemistry, University of Tuebingen, Auf
der Morgenstelle 18, D-72076 Tuebingen, Germany, Email: ivana.fleischer
uni-tuebingen.de
V. Hirschbeck, P. H. Gehrtz, I. Fleischer, J. Am. Chem. Soc., 2016, 138, 16794-16799.
DOI: 10.1021/jacs.6b11020
see article for more reactions
Abstract
The combination of thiols as nucleophiles and a bidentate ligand enable a palladium-catalyzed thiocarbonylation of styrene derivatives with high regioselectivity toward the more valuable branched isomer. The ambient reaction conditions (temperature, catalyst loading) and the use of a CO surrogate render this transformation a useful method for the synthesis of thioesters.
see article for more examples
Key Words
ID: J48-Y2016
