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Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides

Weigao Hu, Jia Zheng, Jianxiao Li, Bifu Liu, Wanqing Wu, Haiyang Liu* and Huanfeng Jiang*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China, Email: chhyliuscut.edu.cn, jianghfscut.edu.cn

W. Hu, J. Zheng, J. Li, B. Liu, W. Wu, H. Liu, H. Jiang, J. Org. Chem., 2016, 81, 12451-12458.

DOI: 10.1021/acs.joc.6b02227 (free Supporting Information)



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Abstract

An efficient and convenient palladium-catalyzed cyclization reaction of alkynes with isocyanides followed by hydrolysis enables a practical synthesis of a broad range of valuable polysubstituted maleimide derivatives under mild reaction conditions. Isocyanide serve as both C and N sources.


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Key Words

maleimides


ID: J42-Y2016