Copper-Catalyzed Tandem Reaction of 2-Aminobenzamides with Tertiary Amines for the Synthesis of Quinazolinone Derivatives
Wei Xu, Xiao-Rui Zhu, Peng-Cheng Qian, Xing-Guo Zhang, Chen-Liang Deng*
*College of Chemistry and Materials Engineering, Wenzhou
University, Wenzhou 325035, P. R. of China, Email: dcl78
wzu.edu.cn
W. Xu, X.-R. Zhu, P.-C. Qian, X.-G. Zhang, C.-L. Deng, Synlett, 2016, 27, 2851-2857.
DOI: 10.1055/s-0036-1588881
see article for more reactions
Abstract
A copper-catalyzed tandem reaction of 2-aminobenzamides with tertiary amines provides quinazolinone derivatives. A broad range of substrates reacted under the standard conditions to give the corresponding quinazolinone derivatives in good yields.
see article for more examples
proposed reaction pathway
Key Words
copper catalysis, tandem reactions, aminobenzamides, tertiary amines, quinazolinones, oxygen, DDQ
ID: J60-Y2016
