Organic Chemistry Portal



Copper-Catalyzed Tandem Reaction of 2-Aminobenzamides with Tertiary Amines for the Synthesis of Quinazolinone Derivatives

Wei Xu, Xiao-Rui Zhu, Peng-Cheng Qian, Xing-Guo Zhang, Chen-Liang Deng*

*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China, Email:

W. Xu, X.-R. Zhu, P.-C. Qian, X.-G. Zhang, C.-L. Deng, Synlett, 2016, 27, 2851-2857.

DOI: 10.1055/s-0036-1588881

see article for more reactions


A copper-catalyzed tandem reaction of 2-aminobenzamides with tertiary amines provides quinazolinone derivatives. A broad range of substrates reacted under the standard conditions to give the corresponding quinazolinone derivatives in good yields.

see article for more examples

proposed reaction pathway

Key Words

copper catalysis, tandem reactions, aminobenzamides, tertiary amines, quinazolinones, oxygen, DDQ

ID: J60-Y2016