Cobalt-Catalyzed C(sp²)-C(sp³) Cross-Coupling Reactions of Diarylmanganese Reagents with Secondary Alkyl Iodides

Maximilian S. Hofmayer, Jeffrey M. Hammann, Diana Haas and Paul Knochel*

*Department of Chemistry, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 München, Germany, Email: paul.knochelcup.uni-muenchen.de

M. S. Hofmayer, J. M. Hammann, D. Haas, P. Knochel, Org. Lett., 2016, 18, 6456-6459.

DOI: 10.1021/acs.orglett.6b03349

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Abstract

A CoCl₂·2LiCl-catalyzed cross-coupling of diarylmanganese reagents with secondary alkyl iodides provides the cross-coupling products in good yield without rearrangements to unbranched products. High diastereoselectivities can be reached.

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Key Words

alkylation

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ID: J54-Y2016