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Iron-Catalyzed C-H Alkylation of Heterocyclic C-H Bonds

Kaki Raveendra Babu, Nengbo Zhu and Hongli Bao*

*State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, P. R. China, Email:

K. R. Babu, N. Zhu, H. Bao, Org. Lett., 2017, 19, 46-49.

DOI: 10.1021/acs.orglett.6b03287

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The use of alkyl diacyl peroxides and alkyl tert-butyl peresters, which are readily accessible from carboxylic acids, enables an efficient, iron-catalyzed C-H alkylation of benzothiazoles. This reaction is environmentally benign and compatible with a broad range of functional groups. Various primary, secondary, and tertiary alkyl groups can be efficiently incorporated.

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proposed mechanism

Key Words


ID: J54-Y2017