Organic Chemistry Portal



Synthesis of Quinolines through Three-Component Cascade Annulation of Aryl Diazonium Salts, Nitriles, and Alkynes

Hao Wang, Qian Xu, Sheng Shen* and Shouyun Yu*

*School of Medicine, Nanjing University, Nanjing 210008; School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China, Email:,

H. Wang, Q. Xu, S. Shen, S. Yu, J. Org. Chem., 2017, 82, 770-775.

DOI: 10.1021/acs.joc.6b02509

see abstract for more reactions


A three-component cascade annulation of readily available aryl diazonium salts, nitriles, and alkynes enables an efficient, additive-free, and rapid synthesis of multiply substituted quinolines in good yields. Various aryl diazonium salts, nitriles, and alkynes can participate in this transformation.

see article for more examples

proposed mechanism

Key Words

quinolines, multicomponent reactions

ID: J42-Y2017