Synthesis of Quinolines through Three-Component Cascade Annulation of Aryl Diazonium Salts, Nitriles, and Alkynes
Hao Wang, Qian Xu, Sheng Shen* and Shouyun Yu*
*School of Medicine, Nanjing University, Nanjing 210008;
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing
210023, China, Email: txdqxdl1979
163.com, yushouyunnju.edu.cn
H. Wang, Q. Xu, S. Shen, S. Yu, J. Org. Chem., 2017, 82, 770-775.
see abstract for more reactions
Abstract
A three-component cascade annulation of readily available aryl diazonium salts, nitriles, and alkynes enables an efficient, additive-free, and rapid synthesis of multiply substituted quinolines in good yields. Various aryl diazonium salts, nitriles, and alkynes can participate in this transformation.
see article for more examples
proposed mechanism
Key Words
quinolines, multicomponent reactions
ID: J42-Y2017
