P(NMe2)3-Mediated Aziridination of Imines with α-Ketoesters for Synthesis of Aziridine-2-carboxylates
Jin Jiang, Hui Liu, Chong-Dao Lu* and Yan-Jun Xu*
*Key Laboratory of Plant Resources and Chemistry of Arid Zones, Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830011, China, Email: clums.xjb.ac.cn, xuyjms.xjb.ac.cn
J. Jiang, H. Liu, C.-D. Lu, Y.-J. Xu, J. Org. Chem., 2017, 82, 811-818.
DOI: 10.1021/acs.joc.6b02669 (free Supporting Information)
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Adducts derived from P(NMe2)3 and α-ketoesters are effectively intercepted by N-sulfonyl imines, affording a range of aziridine-2-carboxylates. The diastereoselectivity of this aziridination depends on steric hindrance from substituents on the substrates.
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