Burgess Reagent Facilitated Alcohol Oxidations in DMSO
Prakash R. Sultane and Christopher W. Bielawski*
*Institute for Basic Science (IBS) & Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea, Email: bielawskiunist.ac.kr
P. R. Sultane, C. W. Bielawski, J. Org. Chem., 2017, 82, 1046-1052.
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In the presence of dimethyl sulfoxide, the Burgess reagent efficiently and rapidly facilitates the oxidation of a broad range of primary and secondary alcohols to their corresponding aldehydes and ketones in excellent yields and under mild conditions. This oxidation can be combined with Wittig olefinations. A mechanism similar to those described for the Pfitzner-Moffatt and Swern oxidations is proposed.
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Burgess reagent, DMSO, aldehydes, ketones