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Cobalt-Catalyzed Carbozincation of Ynamides

Romain Sallio, Martin Corpet, Loic Habert, Muriel Durandetti, Corinne Gosmini* and Isabelle Gillaizeau*

*Université Paris Saclay, 91128 Palaiseau Cedex; Université d'Orléans, rue de Chartres, 45100 Orléans, France, Email:,

R. Sallio, M. Corpet, L. Habert, M. Durandetti, C. Gosmini, I. Gillaizeau, J. Org. Chem., 2017, 82, 1254-1259.

DOI: 10.1021/acs.joc.6b02612 (free Supporting Information)

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A cobalt-catalyzed ynamide carbozincation provides diverse 3-aryl enamides with mild reaction conditions and good functional-group tolerance. This reaction displays an excellent regio- and total stereoselectivity. Moreover, this approach allows the selective synthesis of biologically relevant 3,5-disubstituted oxazolone frameworks.

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proposed mechanism

Key Words


ID: J42-Y2017