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Iodine-Catalyzed Direct C-H Alkenylation of Azaheterocycle N-Oxides with Alkenes

Zhenhao Zhang, Chao Pi, Heng Tong, Xiuling Cui* and Yangjie Wu*

*Department of Chemistry, Zhengzhou University, Zhengzhou 450052, P. R. China, Email:,

Z. Zhang, C. Pi, H. Tong, X. Cui, Y. Wu, Org. Lett., 2017, 19, 440-443.

DOI: 10.1021/acs.orglett.6b03399

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An efficient and regioselective alkenylation of azaheterocycle N-oxides with alkenes is catalyzed by iodine under metal- and external oxidant-free reaction conditions to provide various (E)-2-styrylazaheterocycles in good yields. The N-oxide group plays a dual role as both the directing group and an internal oxidant.

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Key Words


ID: J54-Y2017