Free-Radical Bromotrifluoromethylation of Olefin via Single-Electron Oxidation of NaSO₂CF₃ by NaBrO₃

Zhong-Quan Liu* and Dong Liu

*State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, P. R. China, Email: liuzhqlzu.edu.cn

Z.-Q. Liu, D. Liu, J. Org. Chem., 2017, 82, 1649-1656.

DOI: 10.1021/acs.joc.6b02812

---

see article for more reactions

Abstract

The use of NaSO₂CF₃ and NaBrO₃ enables a free-radical bromotrifluoromethylation of olefins. Sodium bromate acts not only as a single-electron oxidant but also as a bromine source.

see article for more examples

proposed mechanism

---

---

Key Words

trifluoromethylation, bromination, sodium bromate

---

ID: J42-Y2017