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Multicomponent Approach for the Synthesis of Substituted 1,8-Naphthyridine Derivatives Catalyzed by N-Bromosulfonamides

Ramin Ghorbani-Vaghei*, Seyedeh Mina Malaekehpoor

*Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, 6517838683, Hamedan, Iran, Email:

R. Ghorbani-Vaghei, S. M. Malaekehpoor, Synthesis, 2017, 49, 763-769.

DOI: 10.1055/s-0036-1588886

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A single-step, facile synthesis of 1,8-naphthyridine derivatives in good yields was carried out at room temperature under mild conditions using a three-component condensation reaction of substituted 2-aminopyridines, malononitrile or methyl/ethyl cyanoacetate, and various aldehydes in the presence of a N-bromosulfonamide as Lewis acid.

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Key Words

1,8-naphthyridines, N-bromosulfonamides, 2-aminopyridine, Knoevenagel/Michael addition, heterocyclization, multicomponent reactions

ID: J66-Y2017