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Palladium-Catalyzed Direct Intramolecular C-N Bond Formation: Access to Multisubstituted Dihydropyrroles

Bing Jiang, Fei-Fan Meng, Qiu-Ju Liang, Yun-He Xu* and Teck-Peng Loh*

*University of Science and Technology of China, Hefei 230026, China; School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Email: xyh0709ustc.edu.cn, teckpengntu.edu.sg

B. Jiang, F.-F. Meng, Q.-J. Liang, Y.-H. Xu, T.-P. Loh, Org. Lett., 2017, 19, 914-917.

DOI: 10.1021/acs.orglett.7b00072



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Abstract

A palladium-catalyzed intramolecular amination of alkenes with tosyl-protected amines was achieved under mild reaction conditions in the presence of chloranil to provide versatile dihydropyrrole derivatives with retention of olefin functionalization in good yields.

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proposed mechanism



Key Words

2-pyrrolines, chloranil


ID: J54-Y2017