α-Imino Gold Carbenes from 1,2,4-Oxadiazoles: Atom-Economical Access to Fully Substituted 4-Aminoimidazoles
Zhongyi Zeng, Hongming Jin, Jin Xie, Bing Tian, Matthias Rudolph, Frank Rominger and A. Stephen K. Hashmi*
*Organisch-Chemisches Institut, Ruprecht-Karls-Universität
Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany,
Email: hashmi
hashmi.de
Z. Zeng, H. Jin, J. Xie, B. Tian, M. Rudolph, F. Rominger, A. S. K. Hashmi, Org. Lett., 2017, 19, 1020-1023.
DOI: 10.1021/acs.orglett.7b00001
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Abstract
A gold-catalyzed selective [3 + 2] annulation of 1,2,4-oxadiazoles with ynamides enables an atom-economical synthesis of fully substituted 4-aminoimidazoles. The reaction proceeds with 100% atom economy, exhibits good functional group tolerance, and can be conducted in gram scale.
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Key Words
ID: J54-Y2017
