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Nickel-Catalyzed Synthesis of Quinazolinediones

Gregory L. Beutner* , Yi Hsiao, Thomas Razler, Eric M. Simmons and William Wertjes

*Chemical and Synthetic Development, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903-0191, United States, Email:

G. L. Beutner, Y. Hsiao, T. Razler, E. M. Simmons, W. Wertjes, Org. Lett., 2017, 19, 1052-1055.

DOI: 10.1021/acs.orglett.7b00052

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XANTPHOS has been identified as the optimal ligand for a nickel(0)-catalyzed synthesis of quinazolinediones from isatoic anhydrides and isocyanates. Preliminary results on an asymmetric synthesis of atropisomeric quinazolinediones are reported too.

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Key Words


ID: J54-Y2017