Enantioselective Alkyne Conjugate Addition Enabled by Readily Tuned Atropisomeric P,N-Ligands
Sourabh Mishra, Ji Liu and Aaron Aponick*
*Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611, United States, Email: aponickchem.ufl.edu
S. Mishra, J. Liu, A. Aponick, J. Am. Chem. Soc., 2017, 139, 3352-3355.
DOI: 10.1021/jacs.7b00363 (free Supporting Information)
see article for more reactions
The use of Me-StackPhos as ligand enables a Cu-catalyzed enantioselective conjugate alkynylation of Meldrum’s acid acceptors. The reaction tolerates a wide range of alkynes furnishing highly useful β-alkynyl Meldrum's acid building blocks in high yields and excellent enantioselectivity.
see article for more examples
Transformations of β-Alkynyl Meldrum’s Acids
F. S. P. Cardoso, K. Abboud, A. Aponick, J. Am. Chem. Soc., 2013, 135, 14548-14551.