Solvent-Directed Epoxide Opening with Primary Amines for the Synthesis of β-Amino Alcohols
Joseph R. Lizza, Gustavo Moura-Letts*
*Chemistry and Biochemistry Department, Rowan University, Glassboro, NJ 08028, USA, Email: moura-lettsrowan.edu
J. R. Lizza, G. Moura-Letts, Synthesis, 2017, 49, 1231-1242.
DOI: 10.1055/s-0036-1588356 (free Supporting Information)
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A variety of polar mixed solvent systems enable an efficient and regioselective synthesis of β-amino alcohols from a variety of epoxides and primary amines in high yields in the absence of any catalyst.
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β-amino alcohols, primary amines, epoxide opening reactions, solvent-directed reactions, β-blockers