Enantioselective Terminal Addition to Allenes by Dual Chiral Primary Amine/Palladium Catalysis
Han Zhou, Yaning Wang, Long Zhang, Mao Cai and Sanzhong Luo*
*Key Laboratory for Molecular Recognition and Function,
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, Email:
Luosz
iccas.ac.cn
H. Zhou, Y. Wang, L. Zhang, M. Cai, S. Luo, J. Am. Chem. Soc., 2017, 139, 3631-3634.
DOI: 10.1021/jacs.7b00437
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Abstract
A synergistic chiral primary amine/achiral palladium catalyzed enantioselective terminal addition to allenes with α-branched β-ketocarbonyls and aldehydes affords allylic adducts bearing acyclic all-carbon quaternary centers with high regio- and enantioselectivity. A wide range of allenes can be employed.
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proposed mechanism
Key Words
ID: J48-Y2017
