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Assembly of Diversely Substituted Quinolines via Aerobic Oxidative Aromatization from Simple Alcohols and Anilines

Jixing Li, Jinlong Zhang, Huameng Yang and Gaoxi Jiang*

*State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou 730000, P. R. China, Email:

J. Li, J. Zhang, H. Yang, G. Jiang, J. Org. Chem., 2017, 82, 3245-3251.

DOI: 10.1021/acs.joc.6b03064

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Pd(OAc)2/2,4,6-Collidine/Brønsted acid catalyze an aerobic oxidative aromatization of simple aliphatic alcohols and anilines to provide diverse substituted quinoline derivatives in high yields with wide functional group tolerance. Practically, the protocol can be easily scaled up to gram-scale.

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Key Words

quinolines, oxygen

ID: J42-Y2017