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Efficient Ruthenium(II)-Catalyzed Direct Reductive Amination of Aldehydes under Mild Conditions Using Hydrosilane as the Reductant

Bin Li*, Jianxiong Zheng, Weifeng Zeng, Yibiao Li*, Lu Chen

*School of Chemical & Environmental Engineering, Wuyi University, Jiangmen 529020, Guangdong Province, P. R. of China, Email: binliwyu.edu.cn, leeyib268126.com

B. Li, J. Zheng, W. Zeng, Y. Li, L. Chen, Synthesis, 2017, 49, 1349-1355.

DOI: 10.1055/s-0036-1588092 (free Supporting Information)



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Abstract

The [RuCl2(p-cymene)]2/Ph2SiH2 catalytic system is very efficient for the reductive amination of aldehydes with anilines to provide secondary amines and tertiary amines in good yields. The method is highly chemoselective and tolerates a wide range of functional groups, such as NO2, CN, CO2Me, F, Cl, Br, OMe, Me, furyl and alkyl.

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Key Words

ruthenium catalysis, diphenylsilane, reductive amination, amines, aldehydes, aryl amines


ID: J66-Y2017