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Silver-Catalyzed C(sp3)-H Chlorination

Jun Ozawa and Motomu Kanai

*Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email:

J. Ozawa, M. Kanai, Org. Lett., 2017, 19, 1430-1433.

DOI: 10.1021/acs.orglett.7b00367

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A silver-catalyzed chlorination of benzylic, tertiary, and secondary C(sp3)-H bonds proceeded with as low as 0.2 mol % catalyst loading at room temperature under air atmosphere with synthetically useful functional group compatibility.

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Key Words

chlorination, tert-butyl hypochlorite

ID: J54-Y2017