Copper(II)-Catalyzed Selective Reductive Methylation of Amines with Formic Acid: An Option for Indirect Utilization of CO₂

Chang Qiao, Xiao-Fang Liu, Xi Liu and Liang-Nian He*

*State Key Laboratory and Institute of Elemento-Organic Chemistry and Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China, Email: helnnankai.edu.cn

C. Qiao, X.-F. Liu, X. Liu, L.-N. He, Org. Lett., 2017, 19, 1490-1493.

DOI: 10.1021/acs.orglett.7b00551

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Abstract

A copper-catalyzed protocol for reductive methylation of amines and imine with formic acid as a C1 source and phenylsilane as a reductant provides the corresponding methylamines in good to excellent yields under mild conditions.

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Key Words

reductive amination, anilines, phenylsilane

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ID: J54-Y2017