Copper(II)-Catalyzed Selective Reductive Methylation of Amines with Formic Acid: An Option for Indirect Utilization of CO2
Chang Qiao, Xiao-Fang Liu, Xi Liu and Liang-Nian He*
*State Key Laboratory and Institute of Elemento-Organic Chemistry and Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China, Email: helnnankai.edu.cn
C. Qiao, X.-F. Liu, X. Liu, L.-N. He, Org. Lett., 2017, 19, 1490-1493.
DOI: 10.1021/acs.orglett.7b00551 (free Supporting Information)
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A copper-catalyzed protocol for reductive methylation of amines and imine with formic acid as a C1 source and phenylsilane as a reductant provides the corresponding methylamines in good to excellent yields under mild conditions.
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