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Synthesis of Indoles from 2-Vinylanilines with PIFA or TFA and Quinones

Mingzhong Wu, Rulong Yan*

*State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou 730000, Gansu, P. R. of China, Email:

M. Wu, R. Yan, Synlett, 2017, 28, 729-733.

DOI: 10.1055/s-0036-1588122

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The use of PIFA {[bis(trifluoroacetoxy)iodo]benzene} or quinones enables a cyclization of 2-vinylanilines to provide various indoles under mild conditions in good yields.

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Key Words

2-vinylanilines, PIFA, quinones, oxidant, indoles

ID: J60-Y2017