Organic Chemistry Portal



Synthesis of 2-Acylbenzo[b]thiophenes via Cu-Catalyzed α-C-H Functionalization of 2-Halochalcones Using Xanthate

Subramani Sangeetha and Govindasamy Sekar*

*Department of chemistry, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India, Email:

S. Sangeetha, G. Sekar, Org. Lett., 2017, 19, 1670-1673.

DOI: 10.1021/acs.orglett.7b00462

see article for more reactions


α-C-H functionalization using Cu(OAc)2 as catalyst and xanthate as sulfur source enables an efficient synthesis of 2-acylbenzo[b]thiophenes from easily accessible 2-iodochalcones. Less reactive 2-bromochalcones also yielded the corresponding 2-acylbenzothiophenes in good yield. The reaction proceeds via in situ incorporation of sulfur followed by copper-catalyzed cyclization.

see article for more examples

Key Words


ID: J54-Y2017