A Ligand-Directed Catalytic Regioselective Hydrocarboxylation of Aryl Olefins with Pd and Formic Acid

Wei Liu , Wenlong Ren, Jingfu Li, Yuan Shi, Wenju Chang and Yian Shi*

*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States, Email: Yian.Shicolostate.edu

W. Liu, W. Ren, J. Li, Y. Shi, W. Chang, Y. Shi, Org. Lett., 2017, 19, 1748-1751.

DOI: 10.1021/acs.orglett.7b00507

---

Abstract

An effective Pd-catalyzed hydrocarboxylation of aryl olefins with formic acid and Ac₂O provides 2- and 3-arylpropanoic acids regioselectively, depending on the judicious choice of ligand, without the use of toxic CO gas.

see article for more examples

---

---

Pd-Catalyzed Highly Chemo- and Regioselective Hydrocarboxylation of Terminal Alkyl Olefins with Formic Acid

W. Ren, J. Chu, F. Sun, Y. Shi, Org. Lett., 2019, 21, 5967-5970.

An Effective Pd-Catalyzed Regioselective Hydroformylation of Olefins with Formic Acid

W. Ren, W. Chang, J. Dai, Y. Shi, J. Li, Y. Shi, J. Am. Chem. Soc., 2016, 138, 14864-14867.

Palladium-Catalyzed Highly Regio- and Enantioselective Hydroesterification of Aryl Olefins with Phenyl Formate

J. Li, W. Chang, W. Ren, J. Dai, Y. Shi, Org. Lett., 2016, 18, 5456-5459.

Facile Palladium-Catalyzed Hydrocarboxylation of Olefins without External CO Gas

Y. Wang, W. Ren, J. Li, H. Wang, Y. Shi, Org. Lett., 2014, 16, 5960-5963.

---

Key Words

hydrocarboxylation

---

ID: J54-Y2017