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Oxidation of β-Ketoamides: The Synthesis of Vicinal Tricarbonyl Amides

Yueyang Liu, Zhiguo Zhang*, Yameng Wan, Guisheng Zhang*, Zhonglian Li, Jingjing Bi, Nana Ma, Tongxin Liu and Qingfeng Liu

*School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P. R. China, Email:,

Y. Liu, Z. Zhang, Y. Wan, G. Zhang, Z. Li, J. Bi, N. Ma, T. Liu, Q. Liu, J. Org. Chem., 2017, 82, 3901-3907.

DOI: 10.1021/acs.joc.6b03062

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The use of phenyliodine(III) bis(trifluoroacetate) enables a facile and direct oxidation of readily available β-ketoamides to provide vicinal tricarbonyl amides in good yields. This approach is a valuable addition to the group of traditional methods already available.

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Key Words

α-keto amides, PIFA

ID: J42-Y2017