Tf2NH-Catalyzed Formal [3 + 2] Cycloaddition of Ynamides with Dioxazoles: A Metal-Free Approach to Polysubstituted 4-Aminooxazoles
Yingying Zhao, Yancheng Hu, Chunxiang Wang, Xincheng Li* and Boshun Wan*
*Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China, Email: xclidicp.ac.cn, bswandicp.ac.cn
Y. Zhao, Y. Hu, C. Wang, X. Li, B. Wan, J. Org. Chem., 2017, 82, 3935-3942.
DOI: 10.1021/acs.joc.7b00076
see article for more reactions
Abstract
An unprecedented Tf2NH-catalyzed formal [3 + 2] cycloaddition of ynamides with dioxazoles enables a metal-free assembly of various polysubstituted 4-aminooxazoles. This approach features a low-cost catalyst, exceptionally mild reaction conditions, a very short reaction time, broad substrate scope, and high efficiency.
see article for more examples
Key Words
ID: J42-Y2017