Organic Chemistry Portal



Synthesis of Indolizines via Reaction of 2-Substitued Azaarenes with Enals by an Amine-NHC Relay Catalysis

Hongxian Li, Xiangmin Li, Yang Yu, Jianjun Li, Yuan Liu, Hao Li* and Wei Wang*

*Shanghai Key Laboratory of New Drug Design, and School of Pharmacy, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China, Email:,

H. Li, X. Li, Y. Yu, J. Li, Y. Liu, H. Li, W. Wang, Org. Lett., 2017, 19, 2010-2013.

DOI: 10.1021/acs.orglett.7b00566

see article for more reactions


A metal-free catalytic strategy for the facile synthesis of biologically relevant indolizines and imidazopyridines is promoted by amine and N-heterocyclic carbene (NHC) relay catalysis via Michael addition-[3 + 2] fusion of simple azaarenes and α,β-unsaturated aldehydes.

see article for more examples

Key Words

Indolizines, Organocatalysis, PIDA

ID: J54-Y2017