Synthesis of Indolizines via Reaction of 2-Substitued Azaarenes with Enals by an Amine-NHC Relay Catalysis
Hongxian Li, Xiangmin Li, Yang Yu, Jianjun Li, Yuan Liu, Hao Li* and Wei Wang*
*Shanghai Key Laboratory of New Drug Design, and School of Pharmacy, East China University of Science and Technology, 130 Mei-long Road, Shanghai 200237, China, Email: hli77ecust.edu.cn, wwangunm.edu
H. Li, X. Li, Y. Yu, J. Li, Y. Liu, H. Li, W. Wang, Org. Lett., 2017, 19, 2010-2013.
DOI: 10.1021/acs.orglett.7b00566 (free Supporting Information)
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A metal-free catalytic strategy for the facile synthesis of biologically relevant indolizines and imidazopyridines scaffolds is promoted by amine and N-heterocyclic carbene (NHC) relay catalysis via Michael addition-[3 + 2] fusion of simple azaarenes and α,β-unsaturated aldehydes.
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