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Synthesis of N-Aryl Amides by Ligand-Free Copper-Catalyzed ipso-Amidation of Arylboronic Acids with Nitriles

Yan Qiao, Gaoqiang Li*, Sha Liu, Yujie Yangkai, Jingxuan Tu, Feng Xu*

*Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi 710062, P. R. China, Email:,

Y. Qiao, G. Li, S. Liu, Y. Yangkai, J. Tu, F. Xu, Synthesis, 2017, 49, 1834-1838.

DOI: 10.1055/s-0036-1588373

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A facile copper-catalyzed ipso-amidation of arylboronic acids with nitriles enables a highly efficient and economical synthesis of N-aryl amides with a broad substrate scope.

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Key Words

amides, nitriles, amination, copper catalysis, arylboronic acids, Chan-Lam coupling, hydrolysis, tandem reactions

ID: J66-Y2017