Synthesis of N-Aryl Amides by Ligand-Free Copper-Catalyzed ipso-Amidation of Arylboronic Acids with Nitriles
Yan Qiao, Gaoqiang Li*, Sha Liu, Yujie Yangkai, Jingxuan Tu, Feng Xu*
*Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi 710062, P. R. China, Email: gqlisnnu.edu.cn, fengxusnnu.edu.cn
Y. Qiao, G. Li, S. Liu, Y. Yangkai, J. Tu, F. Xu, Synthesis, 2017, 49, 1834-1838.
DOI: 10.1055/s-0036-1588373 (free Supporting Information)
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A facile copper-catalyzed ipso-amidation of arylboronic acids with nitriles enables a highly efficient and economical synthesis of N-aryl amides with a broad substrate scope.
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