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Synthesis of Selectively Substituted or Deuterated Indenes via Sequential Pd and Ru Catalysis

Anupam Jana, Kasjan Misztal, Anna Żak and Karol Grela*

*Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland, Email:

A. Jana, K. Misztal, A. Żak, K. Grela, J. Org. Chem., 2017, 82, 4226-4234.

DOI: 10.1021/acs.joc.7b00200 (free Supporting Information)

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Readily available substituted phenols are used as starting materials in a reaction sequence composed of Pd-catalyzed Suzuki coupling and Ru-catalyzed ring-closing metathesis for the controlled construction of functionalized indene derivatives in excellent yields. This approach is also utilized for the synthesis of substituted indenes selectively deuterated in position 3.

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Key Words

Indenes, Ring Closing Metathesis

ID: J42-Y2017