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Thiocarbonyl Surrogate via Combination of Sulfur and Chloroform for Thiocarbamide and Oxazolidinethione Construction

Wei Tan, Jianpeng Wei and Xuefeng Jiang*

*School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, P. R. China, Email:

W. Tan, J. Wei, X. Jiang, Org. Lett., 2017, 19, 2166-2169.

DOI: 10.1021/acs.orglett.7b00819 (free Supporting Information)

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The combination of sulfur and chloroform enables an efficient and practical synthesis of a thiocarbonyl surrogate. Various thiocarbamides and oxazolidinethiones have been synthesized, including chiral thiourea catalysts and chiral oxazolidinethione auxiliaries with high selectivity.

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Key Words

amination, thionation

ID: J54-Y2017