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Nickel-Catalyzed Direct Synthesis of Aryl Olefins from Ketones and Organoboron Reagents under Neutral Conditions

Chuanhu Lei, Yong Jie Yip and Jianrong Steve Zhou*

*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, SPMS-CBC-06-03, Singapore 637371, Singapore, Email: jrzhountu.edu.sg

C. Lei, Y. J. Yip, J. S. Zhou, J. Am. Chem. Soc., 2017, 139, 6086-6089.

DOI: 10.1021/jacs.7b02742 (free Supporting Information)


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Abstract

A nickel-catalyzed addition of arylboron reagents to ketones provides olefins. The neutral reaction conditions allow acidic protons of alcohols, phenols, and malonates to be present, and fragile structures are also tolerated.


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Key Words

arylation


ID: J48-Y2017