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One-Pot Synthesis of 3-Substituted 2-Arylpyrrole in Aqueous Media via Addition-Annulation of Arylboronic Acid and Substituted Aliphatic Nitriles

Md Yousuf and Susanta Adhikari*

*Department of Chemistry, University of Calcutta, 92, A.P.C. Road, Kolkata 700 009, India, Email:

M. Yousuf, S. Adhikari, Org. Lett., 2017, 19, 2214-2217.

DOI: 10.1021/acs.orglett.7b00490 (free Supporting Information)

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Pd(II)-catalyzed C-C coupling reactions between substituted aliphatic nitriles and arylboronic acids followed by in situ cyclodehydration provide 3-substituted 2-aryl-1H-pyrroles in aqueous acetic acid. This one-pot synthesis is green, and it conforms to atom economy.

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Key Words

pyrroles, green chemistry

ID: J54-Y2017